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Microencapsulation of Diclofenac Sodium by Nonsolvent Addition Technique
Abstract
Purpose: To prepare, using non-solvent addition technique, diclofenac sodium-ethylcellulose microparticles with modified drug release properties.
Methods: Microparticles were prepared by non-solvent addition phase separation method and characterized by micromeritics, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), x-ray diffraction (XRD), dissolution test and thermal analysis.
Results: The microparticles were whitish, irregular, aggregated, and in the size range of 390 - 442 μm size. Drug embedment efficiency was 89 - 91 %. Characterisation studies indicate that there was no strong chemical interaction between the drug and the polymer in the microparticles. Polymer concentration and sustained release behavior were directly proportional.
Conclusion: Non-solvent addition phase separation is a suitable method for preparing diclofenac sodium-ethylcellulose multi-unit controlled release drug delivery system.
Keywords: Phase separation, Diclofenac sodium, Ethylcellulose, Non-solvent addition, Characterisation.
