Article Sidebar
Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Alginate-Chitosan Particulate System for Sustained Release of Nimodipine
Abstract
Methods: Nimodipine-loaded alginate-chitosan beads were prepared by ionic gelation method using various combinations of chitosan and Ca2+ as cations and alginate as anion. The swelling ability and in
vitro drug release characteristics of the beads were studied at pH 1.2 and 6.8. Infra-red (IR) spectrometry, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), x-ray diffraction (XRD), and atomic absorption spectroscopy (AAS) were also applied to investigate the
physicochemical characteristics of the drug in bead formulations.
Results: The surface morphology, size, and drug loading of the beads varied with increase in the concentration of chitosan and calcium chloride in the gelation medium. The swelling ability of the beads
in different pH media was dependent on the presence of a polyelectrolyte complex in the beads and the pH of the media. Both calcium alginate beads and the beads treated with chitosan failed to release the
drug at pH 1.2 over the period of study. On the other hand, at pH 6.8, calcium alginate beads released approx. 96 % of drug in 6 h, but treatment of the beads with chitosan lowered drug release to 73 %.
Drug release mechanism was either “anomalous transport” or “case-II transport”. Data from characterisation studies indicate that there was no significant change in the physical state of the drug in
the bead formulations
