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Hypoglycemic Effects of Clitoria ternatea Linn. (Fabaceae) in Alloxan-induced Diabetes in Rats
Abstract
ternatea leaves and flowers on serum glucose, glycosylated hemoglobin, and insulin were examined in control and extract-treated diabetic rats. The glycogen content of the liver and skeletal muscles of the
rats was evaluated while the activities of the glycolytic enzyme, glucokinase, and the gluconeogenic enzyme, glucose-6-phosphatase in the liver were assessed. The extracts were administered over a period of 84 days. Results: The aqueous extracts of Clitoria ternatea leaves and flowers significantly (P<0.05) reduced serum glucose, glycosylated hemoglobin and the activities of gluconeogenic enzyme, glucose-6-
phosphatase, but increased serum insulin, liver and skeletal muscle glycogen and the activity of the glycolytic enzyme, glucokinase. For all the biochemical tests performed, the leaf extract-treated rat
showed essentially the same profile as those treated with the flower extract. Conclusion: The present investigation suggests that Clitoria ternatea leaf and flower extracts exhibit antihyperglycaemic effect in rats with alloxan-induced diabetes mellitus.
