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Feb 11, 2025Keywords:
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Main Article Content
Therapeutic potential of methanol extracts of Calocybe indica (mushroom) on cadmium chloride-induced hepato-renal toxicity in rats
Abstract
Purpose: To investigate the efficacy of Calocybe indica extract (CIE) in alleviating liver and kidney toxicity caused by cadmium chloride (CdCl₂) in rats. Methods: Six groups of five rats each were used in this study. Group A was the control while groups B to F received 3 mg/kg CdCl2 subcutaneously. Group B was induced with CdCl2 alone for 21 days. Orally, 100 mg/kg of vitamin C, and 200, 400, and 800 mg/kg of CIE were used to treat groups C, D, E, and F respectively. Data were analyzed using Statistical Packages for Social Sciences (SPSS), and results were presented as mean ± standard deviation (SD). Results: Group B had higher liver and kidney weights, and lower body weight compared to control group (p ≥ 0.05). Treatment with CIE increased body weight in CdCl2-induced rats lowers serum levels of alkaline phosphatase, aspartate aminotransferase, alanine aminotransferase, and total bilirubin, improves liver and kidney function, and significantly increased superoxide dismutase (SOD) activity (p < 0.05). Conclusion: Calocybe indica (CIE) extract increases body weight, lowers serum levels of liver enzymes, improves kidney function and significantly lowers SOD activity. Calocybe indica extract may serve as a potential pharmacological candidate or therapeutic alternative for managing hepato-renal injuries. Subsequent molecular studies to ascertain its bioactive compounds will pave the way for the discovery of drug candidates.
