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Published:
Jan 17, 2025Keywords:
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Phytochemical screening and cytotoxic activities of Enhalus acoroides (L.f.) Royle and Halimeda macroloba Decaisne on cervical cancer cell lines
Abstract
Purpose: To determine the cytotoxic effects of phytochemical compounds in Enhalus acoroides and Halimeda macroloba crude extracts on cervical carcinoma and normal kidney tissue cells.
Methods: Dried Enhalus acoroides and Halimeda macroloba were macerated in ethanol. Then, phytochemical screening was done using thin-layer chromatography (TLC). The cytotoxic activities of extracts against HeLa and SiHa cervical cancer cells were performed using MTT assay.
Results: The H. macroloba extract was highly active against SiHa cells, with an IC50 of 17.22 ± 3.93 μg/mL, and moderately active against HeLa cells, with an IC50 of 36.57 ± 7.26 μg/mL. The E. acoroides extract was moderately active against both HeLa and SiHa cells. Moreover, both extracts exhibited lower toxicity against HEK293 normal kidney cells, with IC50 values of > 80 μg/mL.
Conclusion: These results suggest that E. acoroides and H. macroloba exert potent cytotoxic activity on cervical cancer cells. The mode of action associated with the cytotoxicity of these extracts, and the effect of the combination of the extracts with chemotherapy, should be investigated in subsequent studies.
