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Published:
Feb 11, 2025Keywords:
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Main Article Content
Effect of micropancreatic enzyme on biochemical profile in patients who have undergone cholecystectomy
Abstract
Purpose: To determine the effectiveness of micropancreatic enzymes on biochemical profiles in
patients who have undergone cholecystectomy.
Method: A total of 122 patients with pancreatic exocrine insufficiency who visited the outpatient clinic of
Sorgun State Hospital, Yozgat, Turkey and had undergone cholecystectomy in the last three months
were assigned to study and control groups. Study group (n = 72) received micro pancreatic enzyme
mixture for at least 4 weeks within 3 months of cholecystectomy. Control group (n = 50) with a history of
cholecystectomy did not use any digestive aids or micro pancreatic enzyme mixture during the same
period. Pancreatic insufficiency, water consumption, Vit D, B12, calcium, and lipid profiles were
compared in both groups.
Results: Severity of pancreatic exocrine insufficiency was significantly mild in study group compared to
control group (p < 0.05). In patients who had undergone cholecystectomy, total cholesterol, triglyceride,
high-density lipoprotein and low-density lipoprotein levels after at least 6 weeks were significantly lower
in study group compared to control group (p < 0.05).
Conclusion: Micropancreatic enzyme improves pancreatic function, and lowers lipid levels in patients
who have undergone cholecystectomy. A prospective, randomized controlled study will be useful in
determining the appropriate dosage and duration of use which provides symptomatic relief and
biochemical improvement in patients who have undergone cholecystectomy.
