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Feb 11, 2025Keywords:
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Main Article Content
Antitumor evaluation of hydroxyurea analogue Schiff base metal complexes
Abstract
Purpose: The in vivo and in vitro antitumor activities of hydroxyurea derivative Schiff bases (SBs) metal
complexes were investigated in immortalized human colon cancer cell lines (HT-29 cells) and rat
models.
Methods: For the in vitro studies, three concentrations (5, 10, and 20 μM) of the 1-hydroxy-3-(E)-
pyridine-3-ylmethylidene urea derivative SB (L)-metal complexes (L-Cd, L-Cu, L-Zn) were used to
determine the viability of HT-29 cell line with dimethylsulphoxide (DMSO) as control. On the other hand,
colorectal cancer was induced with subcutaneous administration of azoxymethane (AOM; 15 mg/kg) in
35 Wistar albino rats, which were assigned to five treatment groups consisting of DMSO (negative
control), cisplatin (15 mg/kg, positive control), AOM + L-Cd (25 mg/kg), AOM + L-Cu (25 mg/kg) and
AOM + L-Zn (25 mg/kg) groups, respectively. Tumor formation was observed by macroscopic and
microscopic examinations.
Results: Tumour formation was not observed in the positive control group. The rats treated with AOM
(excluding L-Cu and cisplatin group) displayed severe dysplasia and adenocarcinoma formations in the
oil+DMSO, L-Cd and L-Zn groups. When compared with the cisplatin group in the in vivo studies, the Cu
complex had a more favorable effect against colon cancer.
Conclusion: Consequently, hydroxyurea derivative SB-metal complexes exhibit antiproliferative activity
in both in vitro (p < 0.0001) and in vivo studies.
