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Nov 19, 2024Keywords:
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Main Article Content
Overview of pharmacology and clinical development of small interfering RNA
Abstract
approach in cancer treatment. To produce siRNA, short nucleotide sequences are generated exogenously. siRNA inhibits target gene expression in a sequence-specific manner and initiates RNA interference (RNAi) in cells. SiRNA is a recently popularized nucleic acid-based medication that shows unique promise in the treatment of cancer. Before clinical siRNA delivery devices are created, there are still a lot of challenges to be solved. This review covers the potential targets for siRNA drug design, elucidates the characteristics and advantages of siRNA drugs and provides a summary of the available clinical siRNA therapies for cancer treatment. Therapeutically complex siRNA chemical alterations and delivery systems are described, and bio-responsive materials for siRNA release have been classified. This study will support continued advancements in clinical applications of siRNA by acting as a resource for disseminating information for more accurate and effective targeted delivery systems.
