Article Sidebar
Published:
Nov 19, 2024Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Expression patterns of inflammatory cytokines in multiple sclerosis patients.
Abstract
Purpose: To determine the serum levels of cytokines, interleukins (IL) and tumor necrosis factor (TNF) in multiple sclerosis (MS) patients and compare with those in healthy individuals. Methods: Twenty-two (22) adult patients with MS and 44 healthy controls, matched for age and gender, and visiting the King Abdulaziz University Hospital, Jeddah, Saudi Arabia were divided into groups I and II, respectively. Serum levels of interferon-gamma (IFN-γ), tumor necrosis factor and interleukins were determined for both groups. Cytokine levels were assessed using Luminex® xMAP® technology in 22 Saudi MS patients and 22 matched healthy controls. Results: There were no significant differences in mean age between Group I (30.14 ± 10.51) and Group II (30.22 ± 5.22) participants (p = 0.982). Furthermore, the levels of IFN-γ, IL-6, IL-8, IL-1β and TNF-α in the serum were significantly higher in Group I patients than in controls (p < 0.0001 for all). Furthermore, a strong positive correlation was found between IFN-γ and IL-8 (r = 0.467, p = 0.028) in MS patients. Conclusion: Patients with MS release significant amounts of inflammatory cytokines, which play a crucial role in understanding the clinical course of MS. These findings enhance the understanding of MS pathophysiology and guide future studies toward developing targeted treatments to mitigate disease progression and improve patients’ quality of life.
