Article Sidebar
Published:
Nov 19, 2024Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of Henggu gushang mixture on low back pain, bone transformation, serum IGF-1 and Apelin-13 in elderly patients with osteoporosis
Abstract
Purpose: To investigate the effect of Henggu gushang mixture on low back pain, bone transformation, serum insulin-like growth factor (IGF-1) and apelin-13 (Apelin-13) in elderly patients with osteoporosis. Methods: A total of 80 elderly patients with osteoporosis in Ningbo Rehabilitation Hospital, Ningbo, China were divided randomly and equally into study and control groups. Study group received Henggu Gushang mixture in addition to calcium carbonate D3+ alfacalcidol for three months. Control group received calcium carbonate D3+ alfacalcidol. The effectiveness of therapy, visual analogue scale (VAS), levels of bone transformation markers (procollagen type I N-terminal propeptide (PINP) and type 1 collagen cross-linked C-telopeptide (CTX-1)), serum insulin-like growth factor (IGF-1), and Apelin-13 were compared. Adverse drug reactions were also recorded. Results: Total response rate in the study group was significantly higher compared to control group (p < 0.05). It also showed significantly lower VAS scores after 7 days, 1 and 3 months of treatment compared to control group (p < 0.05). After treatment, the levels of PINP and CTX-1 were significantly lower while serum osteocalcin (OC), IGF-1 and Apelin-13 were significantly higher in the study group compared to control group (p < 0.05). There was no significant difference in the incidence of adverse reactions between the two groups (p > 0.05). Conclusion: Henggu gushang mixture significantly relieves low back pain in elderly patients with osteoporosis, which is beneficial to improving bone transformation and metabolism. Future studies should focus on long-term outcomes using larger sample sizes from multi-center to better assess the therapeutic potential of this combined regimen.
