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Published:
Mar 31, 2025Keywords:
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Main Article Content
Effect of amoxicillin-clavulanate potassium and potential factors influencing umbilical cord separation time in preterm infants
Abstract
Purpose: To investigate the effect of amoxicillin-clavulanate potassium and potential factors influencing
umbilical cord separation time in preterm infants.
Methods: A total of 151 preterm infants admitted to the Neonatology Department, First Affiliated
Hospital of Anhui Medical University, Hefei, China, from November 2020 to June 2021 were selected.
Preterm infants were randomly divided into control and study groups. Control group received 2 %
povidone-iodine and 75 % ethanol application, followed by gentle pressure with a cotton swab while the
study group received amoxicillin-clavulanate potassium applied to the umbilical cord while shaking. The
management interventions were stopped after umbilical cord separation in preterm infants, and the
difference in umbilical cord separation time between the two groups was compared. Factors associated
with preterm birth conditions, hospitalization, and maternal health were identified by univariate and
multivariate logistic regression analyses.
Results: The number of cases with umbilical cord separation time > 14 days was significantly higher in
the study group compared to control group (p < 0.05). The average umbilical cord separation time in the
study group was significantly lower compared to control group (p < 0.05). Univariate analysis revealed
that incubator residence time significantly affects umbilical cord separation time in preterm infants (p <
0.05). Logistic multivariate regression analysis identified incubator residence time as the main factor
influencing umbilical cord separation time in preterm infants.
Conclusion: The use of amoxicillin-clavulanate potassium shortens umbilical cord separation time, and
incubator residence time is the major factor influencing umbilical cord separation in preterm infants.
Further studies should expand the study scale and increase the number of samples used.
