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Published:
Mar 31, 2025Keywords:
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Main Article Content
Effect of nasal irrigation with budesonide and normal saline on patients with chronic rhino-sinusitis surgery
Abstract
Purpose: To investigate the therapeutic effect of budesonide nasal irrigation and saline irrigation in
patients undergoing surgery for chronic rhinosinusitis (CRS).
Methods: One hundred patients scheduled for functional endoscopic sinus surgery (FESS) in Shanghai
Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, China were enrolled. The
patients were divided into study and control groups comprising 50 cases each. The study group
received postoperative budesonide irrigation while control group received normal saline irrigation after
surgery. Post-operative symptoms, signs, and adverse reactions of the patients were compared.
Results: Five weeks post-operation, the visual analogue scale (VAS) scores of nasal congestion, nasal
discharge, nasal itching, sneezing, nasal pain, and the score of nasal endoscopy one week and 4-
weeks after operation were significantly lower compared to control (p < 0.05). There was no significant
difference in nasal bleeding when the packing was removed between the two groups (p > 0.05) after
surgery. Within the first week after surgery, there was no significant difference in occurrence of nasal
malodor (p > 0.05).
Conclusion: Application of budesonide nasal irrigation alleviates post-operative symptoms, reduces
inflammation and improves treatment outcomes. Further studies will be required to comprehensively
investigate the dose effect of budesonide.
