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Mar 31, 2025Keywords:
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Main Article Content
Effect of epidural pre-injection of low-dose chloroprocaine on analgesia during second parturition
Abstract
Purpose: To investigate the anesthetic effect of epidural pre-catheterization with low-concentration
chloroprocaine during the second parturition.
Methods: 180 second-trimester primiparas undergoing epidural analgesia in Maanshan Maternal and
Child Health Care Hospital, Ma'anshan, China were randomly divided into 3 groups, viz, precatheterization
with chloroprocaine (group A), routine chloroprocaine (group B), and routine ropivacaine
(group C), with 60 patients per group. The time of onset of analgesia, visual analogue scale (VAS)
scores, modified Bromage score (MBS) scores, neonatal 1- and 5-min Apgar scores, oxytocin use,
number of cesarean sections, volume of postpartum hemorrhage, and incidence of anesthesia-related
complications were compared among the three groups.
Results: Onset time of anesthesia was significantly shorter in women in groups A and B than in group
C (p < 0.05). The VAS scores at 5 and 15 min after analgesia were lower in groups A and B than in
group C (p < 0.05). There were no significant differences in VAS scores among the three groups from
30 min after analgesia to the end of the first stage of labor (p > 0.05). There were also no significant
differences in MBS scores, neonatal Apgar scores, oxytocin use, number of cesarean sections, volume
of postpartum hemorrhage, and incidence of adverse reactions among the three groups (p > 0.05).
Conclusion: Individualized mode of analgesia involving the administration of low-concentration
chloroprocaine to primiparas using an epidural catheter has timely onset of analgesia, good efficacy,
high safety, rapid metabolism, and minimal adverse reactions. Further studies involving multiple centers
and long-term follow-up are necessary.
