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Published:
Mar 31, 2025Keywords:
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Main Article Content
Distribution and antimicrobial susceptibility of pathogenic micro-organisms in pediatric urinary tract infections
Abstract
Purpose: To investigate the prevalence and distribution of pathogenic microorganisms and
antimicrobial susceptibility in pediatric urinary tract infections (UTIs).
Methods: 150 pediatric patients with UTI diagnosed and treated in Danyang People’s Hospital of
Jiangsu Province, China between January 2020 and December 2022 were enrolled. The distribution of
pathogenic microorganisms was analyzed using microbial culture and antimicrobial susceptibility test
results obtained for major gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and
Klebsiella pneumonia). Based on adherence to antimicrobial susceptibility data, patients were divided
into study (adhered to antimicrobial susceptibility) and control groups (did not adhere to antimicrobial
susceptibility). The efficacy of treatments was compared.
Results: A total of 184 strains of pathogenic microorganisms were cultured from the urine of the 150
patients. Gram-negative bacteria accounted for 75.54 %, while gram-positive bacteria accounted for
24.46 %. Frequently encountered strains were Escherichia coli, Pseudomonas aeruginosa, and
Enterococcus faecalis. Major gram-negative bacteria such as Escherichia coli and Pseudomonas
aeruginosa showed higher sensitivity to cefotaxime, imipenem, furantoin, cefepime-tazobactam and
amikacin, while major Gram-positive bacteria like Enterococcus faecalis showed higher sensitivity to
vancomycin, imipenem and ampicillin-sulbactam. Clinical efficacy in the study group was significantly
higher (p < 0.05) compared to the control group.
Conclusion: The distribution of pathogenic microorganisms in pediatric UTIs is diverse, with Gramnegative
bacteria being the most common pathogens. Further studies should expand the sample size
and broaden the scope of study subjects to comprehensively investigate the distribution of pathogenic
microorganisms in pediatric urinary tract infections.
