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Mar 31, 2025Keywords:
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Main Article Content
Efficacy of tenofovir dipivoxil plus entecavir in patients with HBeAg positive chronic hepatitis B
Abstract
Purpose: To investigate the efficacy of tenofovir disoproxil fumarate (TDF) plus entecavir in patients
with HBeAg positive chronic hepatitis B.
Methods: A total of 124 patients with HBeAg-positive chronic hepatitis who were hospitalized at The
First People's Hospital of Jiangxia District, Wuhan, China were chosen as the subjects. They were then
randomized equally into study and control groups. Control group received entecavir (0.5 mg orally) while
the study group administered TDF (300 mg orally) daily for 48 weeks. Efficacy, liver function,
inflammatory factors, liver fibrosis, and adverse reactions between the two groups were evaluated.
Results: After 12 weeks of treatment, HBeAg and HBV DNA negative seroconversion rates were
significantly higher in the study group compared to control group (p < 0.05). At 24 and 48 weeks after
treatment, alanine transaminase (ALT) normalization rate, HBeAg and HBV DNA negative
seroconversion rate were also significantly higher compared to control group. Levels of heat shock
protein 47 (HSP47), endothelial nitric oxide synthase (eNOS), and major basic protein (MBP) were
significantly lower in study group compared to control group. Levels of hyaluronan (HA), type IC
collagen (IV-C), N-terminal propeptide of procollagen type III (PIIINP), and laminin (LN) were
significantly lower in study group compared to control group (p < 0.05). There was no significant
difference in incidence of adverse reactions between the two groups (p > 0 05).
Conclusion: The combination of ETV and TDF significantly inhibits hepatitis B virus replication, and
reduces inflammatory reactions. Further studies to determine the mechanism of action of tenofovir and
entecavir on hepatitis B virus would be required.
