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Main Article Content
Roxadustat protects rats from cisplatin-induced acute kidney injury
Abstract
Purpose: To investigate the potential protective effect of roxadustat against cisplatin-induced acute
kidney injury (AKI) by evaluating biochemical markers, inflammatory parameters, renal function tests,
and histopathological changes.
Methods: Thirty female Wistar rats were randomized into control group, cisplatin with tap water group,
and cisplatin with roxadustat group. Cisplatin-induced AKI was established by intraperitoneal injection of
cisplatin at 10 mg/kg for seven days. Roxadustat was administered orally at 20 mg/kg/day to the
treatment group. Blood and kidney samples were collected for biochemical and histopathological
analyses respectively.
Results: Roxadustat treatment significantly reduced markers of renal injury (malondialdehyde (MDA),
kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), transforming
growth factor-beta 1 (TGF-beta1)), inflammatory cytokines (tumor necrosis factor-alpha (TNF-α),
interleukin-6 (IL-6), interleukin-18 (IL-18)) compared to the cisplatin group (p < 0.005). In addition,
roxadustat treatment also improved renal function (blood urea nitrogen (BUN), serum creatinine (SCr))
compared to the cisplatin group (p < 0.005). Histopathological examination revealed a significant
decrease in tubular epithelial necrosis and luminal necrotic debris in the roxadustat-treated group (p <
0.005). However, there was no significant difference in tubular dilatation and interstitial inflammation
between groups (p > 0.05).
Conclusion: Roxadustat significantly prevents cisplatin-induced AKI by attenuating renal injury,
reducing inflammation, and improving renal function. This evidence suggests that roxadustat may be a
promising preventive option for patients receiving cisplatin chemotherapy.
