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Published:
Mar 31, 2025Keywords:
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Main Article Content
Dexamethasone-triggered hepatic and renal impairment in albino rats, and its amelioration through royal jelly intervention
Abstract
Purpose: To evaluate the hepato-renal protective effect of royal jelly (RJ) against dexamethasone
(DEX)-induced toxicity in rat models.
Methods: Twenty-four male albino Wistar rats (divided equally into three groups) were administered
DEX with or without RJ while control group received normal saline. The serum levels of aspartate
aminotransferase (AST), alanine aminotransaminase (ALT), creatinine, uric acid, albumin, and hepatic
activities of glucose-6-phosphate dehydrogenase (G6PD) and catalase, as well as levels of glutathione
(GSH) and total protein, were measured. Body, kidney and liver weights, as well as blood glucose
concentrations, were measured, before and after treatment.
Results: Dexamethasone (DEX) produced significant hyperglycemia and hyperuricemia and significant
increases in concentrations of kidney and liver function biomarkers (p < 0.05). These changes were
accompanied by decreased liver levels of GSH, total protein and catalase. These alterations were
significantly reversed in DEX-treated rats given RJ, compared to rats receiving only DEX (p < 0.05).
Body weights were also significantly augmented in DEX-injected rats given RJ, relative to rats given
DEX alone (p < 0.05).
Conclusion: Royal jelly significantly reduces DEX-induced renal and hepatic toxicities, which suggests
its probable therapeutic significance in inhibiting glucocorticoid-mediated adverse reactions. This
phenomenon should be further investigated and the possible mechanism elucidated.
