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Sep 6, 2024Keywords:
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Main Article Content
Effect of intestinal microecological agents on perioperative gastrointestinal function and complications in congenital megacolon
Abstract
Purpose: To investigate the efficacy of intestinal microecological agents in enhancing gastrointestinal function in perioperative period of Hirschsprung disease.
Methods: 30 cases with surgically managed Hirschsprung in The Affiliated Hospital of Guizhou Medical University, China between March 2020 and March 2022, were randomized into control and study groups comprising 15 patients each. Both groups underwent laparoscopic-assisted megacolon-modified Swenson radical surgery. Control group received preoperative oral cefaclor suspension for three days, while the study group received Bacillus subtilis diphtheriae granules in addition to preoperative oral cefaclor suspension for four days prior to surgery, and continued from day 10 to day 24 after surgery. Symptoms, efficacy, safety, intestinal microecology, gastrointestinal function, inflammation, and nutrition were assessed upon admission, and 10 days after surgery. Postoperative complications were compared.
Results: Bacterial counts in both groups increased significantly on Day 10 after surgery compared to the counts at admission (p < 0.05). The study group exhibited significantly higher counts compared to the control group (p < 0.05). The bacilli- to-cocci ratio in the study group did not change significantly (p > 0.05). Nutritional status was significantly higher in the study group compared to control group 10 days after surgery (p < 0.05). Furthermore, the incidence of small bowel colitis was lower in the study group compared to control group. There was no significant difference in the incidence of complications in both groups (p > 0.05).
Conclusion: Perioperative use of intestinal microecological agents effectively corrects dysbiosis, improves gastrointestinal function, regulates nutritional indices, and reduces postoperative complications in patients with Hirschsprung disease. Future studies involving a larger number of participants from different ethnic extractions would be required to improve the quality of results obtained from this investigation.
