Article Sidebar
Published:
Sep 6, 2024DOI:
10.4314/tjpr.v23i8.3Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Assessment of organ weight changes in normal and streptozotocin-induced diabetic rats treated with Olea europaea L. leaf extract
Abstract
Purpose: To evaluate the antidiabetic activity of crude extract of Olea europaea L. (CEOE) leaves in streptozotocin induced-diabetic rats and also to determine its tannin content.
Methods: Thirty (30) male, normoglycemic Wistar rats (170 - 250 g) were randomly divided into five groups of six rats each. Group 1, which served as the normal control group, received distilled water while groups 2 and 3, were administered 200 and 600 mg/kg of CEOE extract daily for 18 days, respectively. Group 4 was given glibenclamide (Glibil; 3 mg/kg) while group 5 served as the untreated diabetic control group. Diabetes was induced with a single intraperitoneal injection of streptozotocin (50 mg/kg) and rats with blood glucose levels ≥ 250 mg/dL were confirmed to be diabetic. The blood glucose concentration, water and feed intake, tannin content of CEOE as well as the weight of organs were determined.
Results: The results showed that O. europea contained a large amount of tannins (806.22 ± 0.036 μg Tannic Acid Equivalent/g Extract). Administration of the extract (200 and 600 mg/kg) significantly decreased polydipsia and polyphagia, and reversed weight loss in rats with diabetes (p < 0.05 and p < 0.01, respectively) in comparison with glibenclamide.
Conclusion: The antidiabetic activity of the crude extract of O. europea was higher than that observed with glibenclamide, thus validating the folkloric use of this plant in diabetes care. Further investigation of Olea europea, including thorough chemical and pharmacological studies, are required.
