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Published:
Apr 14, 2024DOI:
10.4314/tjpr.v23i3.2Keywords:
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Main Article Content
In vitro cytotoxic activity of Sansevieria trifasciata against various cancer cell lines
Abstract
Purpose: To determine the in vitro anticancer properties of Sansevieria trifasciata extracts.
Methods: The cytotoxic activity of n-hexane, ethyl acetate and methanol leaf extracts at different concentrations was assessed against Vero, pancreatic (AsPC-1), lung (A549), esophageal squamous carcinoma (KYSE 150) and rhabdomyosarcoma (RD) cancer cell lines using MTT assay. The apoptosis-inducing potential of selected S. trifasciata leaf extract was determined using a caspase 3/7 assay kit.
Results: Ethyl acetate extract of S. trifasciata leaf showed significant anticancer activity against RD cells and methanol extract against KYSE cells (p < 0.05). Ethyl acetate and methanol extract possessed higher toxicity towards RD and KYSE 150 cell lines and exhibited relatively lower toxicity towards Vero normal cells. Ethyl acetate extract-treated RD cells and KYSE 150 cancer cells had more typical apoptotic morphologic features when compared to normal cells.
Conclusion: Sansevieria trifasciata possesses anticancer activity and provides new insights for future molecular work on investigating its utilization in cancer treatment.
