Article Sidebar
Published:
Feb 5, 2024Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Efficacy of the combination of cyclosporine and sodium hyaluronate eye drops on dry eye syndrome
Abstract
Purpose: To investigate the efficacy and adverse effect of cyclosporine combined with sodium
hyaluronate (SH) eye drops on dry eye syndrome (DES).
Methods: 148 patients with DES treated in Nanjing Drum Tower Hospital Group Suqian Hospital,
Jiangsu Province, China between January 2022 and February 2023 were randomly assigned to control
(70 cases) and study groups (78 cases). Control group was treated with SH eye drop (1 drop each on
both eyes 5 - 6 times a day, for 2 months), while study group was treated with both SH (the same
dosage and use with control group) and cyclosporine eye drop (1 - 2 drops each for both eyes, 4 - 6
times a day, for two months). Tear film stability indices such as schirmer I test (SIT), tear break-up time
(BUT) and corneal fluorescein stain (FL) of both groups were analyzed before and after therapy.
Results: There was no significant difference in BUT, SIT and FL score between the two groups before
treatment. Compared with before treatment, BUT and SIT increased significantly (p < 0.05), while FL
score dropped significantly in both groups after treatment (p < 0.05). After treatment, study group
showed significantly higher BUT and SIT levels, and significantly lower FL score than control group (p <
0.05).
Conclusion: The combination of cyclosporine eye drops with SH eye drops is effective in treating DES.
This combination regimen protects tear film stability, effectively alleviates DES symptoms, improves
ocular surface and meibomian gland function, and also increases lacrimal river height, without
increasing adverse reactions. Further studies will be required, to provide more evidence for clinical
application of this combination regimen.
