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Jul 12, 2023Keywords:
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Main Article Content
Prevalence and determinants of abnormal bone metabolism among Han Chinese diabetes patients: A cross-sectional study
Abstract
Purpose: To determine the prevalence and determinants of abnormal bone metabolism among Han Chinese diabetes patients.
Methods: Epidemiological characteristics, anthropometry, densitometry, clinical parameters, and pathological examinations of 335 Han Chinese type 1 and type 2 diabetes patients were analyzed in relation to bone densitometry.
Results: A total of 86 patients (25 %) were normal (T-score or Z-score of -1 or higher), while 259 patients (75 %) had abnormal bone metabolism (T-score or Z-score less than -1). Among the 259 patients with abnormal bone metabolism, 15 (4 %) had fracture-liable fragility (T-score or Z-score below -3), 112 (32 %) had osteoporosis (T-score or Z-score below -2.5), while 132 (39 %) had osteopenia (Tscore or Z-score between -1 to -2.5). Age > 50 years (p = 0.0411), female sex (p = 0.0391), low body mass index (p = 0.0331), long duration of diabetes (p = 0.0291), low waist-to-hip ratio (p = 0.0336), treatment with metformin or Chinese traditional medicine or insulin (p = 0.0395), abnormal levels of pathological parameters (p = 0.0397), and HbA1c ≥ 7 (p = 0.0123) were independent risk factors for abnormal bone metabolism.
Conclusion: Han Chinese individuals have a risk of abnormal bone metabolism in the diabetic state. Older people, women, patients who took metformin or Chinese traditional medicine or insulin treatment, individuals with abnormal pathological parameters, and those with HbA1c ≥ 7, had reduced bone mineral density. Body mass index and waist-to-hip ratio were protective against abnormal bone metabolism.
