Article Sidebar
Published:
Jun 12, 2023Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Implications of statin metabolism related gene testing in guiding individualized drug use in cardiovascular diseases
Abstract
Purpose: To determine the value of statin metabolism-related gene testing in guiding individualized drug use in cardiovascular and cerebrovascular diseases.
Methodology: A total of 158 eligible patients with cardiovascular and cerebrovascular diseases in the Outpatient Department, Yantai City Yantaishan Hospital, Laishan District, Shandong Province were recruited and assigned based on their diseases to group A (81 patients with coronary heart disease), group B (77 patients with cerebral infarction). The control group comprised 75 healthy individuals.
Results: The GG, GT, and TT genotypes in ABCB1 (2677G > T) in group A had a G allele frequency of 0.556 and a T allele frequency of 0.444, while CC, CT, and TT genotypes in ABCB1 (3435C > T) in group A had a C allele frequency of 0.555 and a T allele frequency of 0.445. Significant differences were observed in the effectiveness of statins in treating patients with different genotypes (p < 0.05).
Conclusion: Genetic testing related to statin metabolism is of significant value in guiding the use of medication in patients with cardiovascular disease, as most of these patients present with dyslipidaemia. Significant individual differences in gene polymorphisms exist between patients with the same disease.
