Article Sidebar
Published:
Apr 19, 2023Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of butylphthalide combined with edaravone d borneol on efficacy in elderly patients with acute cerebral infarction
Abstract
Purpose: To investigate the efficacy of butylphthalide combined with edaravone d-borneol in elderly patients with acute cerebral infarction.
Methods: From October 2020 - October 2021, 166 elderly patients suffering from acute cerebral infarction in Affiliated Hospital of Youjiang Medical College for Nationalities, Baise City, China were selected as the study subjects, and randomly divided into study and control groups, respectively, with 83 patients each. Control group was treated with edaravone d-borneol injection (15 mL of edaravone d-borneol in 100 mL of saline), while the study group was treated with butylphthalide and sodium chloride injection, combined with edaravone d-borneol injection (15 mL of edaravone d-borneol and 30 mL of butylphthalide and sodium chloride in 100 mL of saline). Clinical efficacy, as well as the levels of cytokines, viz, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and IL-8, vascular endothelial function indicators, namely, nitric oxide (NO) and vascular endothelial growth factor (VEGF) as well as oxidative stress indicators, viz, malondialdehyde (MDA), glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) of the two groups were evaluated.
Results: Total efficacy/effectiveness in the study group was 93.98 %, which was significantly higher than 73.49 % in the control group (p < 0.05). Post-treatment, the levels of cytokines, vascular endothelial function and oxidative stress in the two groups were significantly improved compared with the values before treatment (p < 0.05). Furthermore, patients in the study group showed better treatment outcomes when compared with control group (p < 0.05).
Conclusion: The combination of butylphthalide and sodium chloride injection with edaravone d-borneol injection (15 mL of edaravone d-borneol and 30 mL of butylphthalide and sodium chloride in 100 mL of saline) is more effective than edaravone d-borneol injection (15 mL of edaravone d-borneol in 100 mL of saline) alone in the treatment of elderly patients with acute cerebral infarction, as it regulates microcirculation and improves cellular inflammatory state and oxidative stress reaction. However, further clinical trials should be conducted prior to application in clinical practice.
