Article Sidebar
Published:
Jun 4, 2022Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Evaluation of potential drug-drug interactions and adverse drug reactions among chronic kidney disease patients: An experience from United Arab Emirates
Abstract
Purpose: To determine the prevalence and assessing nature of potential drug-drug interactions (pDDIs) and adverse drug reactions (ADRs) among chronic kidney disease (CKD) patients.
Methods: This was a prospective observational study involving adult CKD patients. Occurrence of pDDIs was evaluated using Micromedex database 2.0. Suspected ADRs during the study period were documented and assessed.
Results: Overall prevalence of pDDIs was found to be 85.3 %. A total of 811 pDDIs with 225 different pairs of interacting drugs were identified. Majority of the patients had ≥ 3 pDDIs regardless of type of severity. Thirty-five ADRs were identified in 25 CKD patients. Hyperkalemia was the most-commonly suspected ADR. Logistic regression analysis revealed that age (OR: 1.04, 95 % CI: 1.01 - 107), length of hospital stay (OR: 1.15, 95 % CI: 1.0 - 1.32), presence of comorbidity like diabetes (OR: 9.1, 95 % CI: 3.2 - 25.3) and number of drugs prescribed (OR: 6.88, 95 % CI: 1.5 - 30.0) were positively correlated with occurrence of pDDIs. Length of hospital stay (OR: 1.05, 95 % CI: 0.99 - 1.06) and number of drugs (OR: 0.16, 95 % CI 0.03 - 0.84) were identified as independent predictors of occurrence of ADRs.
Conclusion: Prevalence of pDDIs was high in the study population. A majority of the pDDIs were of major severity type, fair documentation grade, and of unspecified onset. A majority of suspected ADRs were probably of moderate in severity and not preventable type.
