Article Sidebar
Published:
Apr 28, 2022Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effects of different hypertonic resuscitations on traumatic brain injuries and cranioencephalic trauma: A single centre, retrospective analysis
Abstract
Purpose: To compare the efficacies of 3 % (w/v) hypertonic saline, 20 % (w/v) mannitol, and 10 % (w/v) mannitol plus 10 % (v/v) glycerol in the management of intracranial hypertension.
Methods: Patients with intracranial pressure > 20 mmHg received 3 % (w/v) hypertonic saline (HT cohort, n = 78) or 20 % w/v mannitol (MT cohort, n = 82) or 10 % (w/v) mannitol plus 10 % (v/v) glycerol (MG cohort, n = 73) until intracranial pressure was reduced below 15 mmHg. Neurologic outcomes, hemodynamic parameters, and clinical biochemistry were evaluated as indices of intracranial pressure and pathological parameters.
Results: Serum sodium levels and serum osmolarity were significantly increased by 3 % (w/ v) hypertonic saline, relative to the other hypertonic resuscitations. At the end of 1 h observation period, 60 (77 %), 36 (44 %), and 41 (56 %) of patients from HT, MT, and MG cohorts, respectively, had their cerebral perfusion pressure successfully maintained at > 70 mmHg. At the end of 1 h observation period, intracranial pressure ≤ 20 mmHg was successfully maintained in 78 (100 %), 81 (99 %), and 73 (100 %) patients from HT, MT, and MG cohorts, respectively. The mean values of arterial pressure of patients in HT, MT, and MG cohorts were increased after 1 h, 15 min, and 30 min of interventions, respectively.
Conclusion: These results indicate that 3 % (w/v) hypertonic saline was the most rapid and most effective resuscitation for the management of intracranial hypertension in traumatic brain injuries or cranioencephalic trauma.
