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Anti-asthmatic effect of fusarubin in an ovalbumin-induced asthmatic rat model
Abstract
Purpose: To investigate the anti-asthmatic effect of fusarubin in an ovalbumin (OVA)-induced asthmatic rat model
Methods: A rat model of asthma was employed in this investigation. Ovalbumin (OVA) was used to sensitise rats, and the rats were then treated with fusarubin before the onset of asthma. Histologybased examinations were conducted to assess the impact of fusarubin on mucus secretion and migration of eosinophils into the lungs.
Results: The results showed that fusarubin significantly decreased ovalbumin-induced airway hyperresponsiveness {AHR levels of inflammatory cells and eosinophils in bronchoalveolar lavage fluid (BALF)}, when compared to the control group (p < 0.05). Furthermore, fusarubin markedly downregulated levels of OVA-stimulated pro-inflammatory cytokines in BAL fluid (p < 0.05).
Conclusion: Fusarubin may be used as a potential novel compound for the management of asthma.
