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Curcumin protects hepatocytes from sepsis by regulating inflammatory response and hepatocyte apoptosis
Abstract
Purpose: To investigate the effect of curcumin on sepsis in rat hepatocytes, and the mechanism involved.
Methods: 60 Wistar rats were used: 45 rats in experimental group, and 15 rats in sham operated group. The expression levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), percentage apoptosis, and protein expression levels of peroxisome proliferator activated receptor (PPAR-γ) and nuclear factorκ B (NF - κ b) were determined.
Results: The levels TNF-α and IL-6 were significantly lower in the curcumin-treated rats than in septic rats, and lower in high-dose curcumin group than in low-dose curcumin group (p < 0.05). The protein expression levels of PPAR-γ in liver tissue of curcumin-treated rats were significantly up-regulated, relative to that in septic rats, but the expression of NF-κ B protein was down-regulated, when compared to that in septic rats (p < 0.05). The protein expression level of PPAR-γ increased in liver tissue of highdose curcumin-exposed rats when compared to the liver tissue of low-dose curcumin rats, while NF-κ B protein was down-regulated in rats given a higher dose of curcumin.
Conclusion: Curcumin reduces inflammatory reaction and suppresses apoptosis of liver cells by upregulating PPAR-γ and down-regulating the expression of NF-κ β, thereby protecting rat hepatocytes from sepsis-induced injury.
