Article Sidebar
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Comparison between air-jet and vibrating-mesh nebulizers in the delivery of nebulized salbutamol sulfate determined using an abbreviated impactor
Abstract
Purpose: To investigate the aerodynamic properties of nebulized droplets from nebulizers for delivery of salbutamol sulfate.
Methods: Drug deposits were collected from fast screening impactor (FSI). Parameters of aerosolization such as dryness time and salbutamol sulfate characteristics were determined using chilled FSI at a flow velocity of 15 L/min, with salbutamol sulfate solution nebulized to dryness. An optimized HPLC procedure was used to analyze the deposited salbutamol sulfate across the FSI. Parameters comprising mass balance, FPD and FPF were determined.
Results: Statistical analysis showed that the performance of vibrating-mesh was more efficient than that of air-jet device, as depicted in significantly higher values FPF of aerosolized droplets (60 and 40 %, respectively; p < 0.05).
Conclusion: The performance of aerosol generation using vibrating-mesh was more superior to that of air-jet nebulizer. However, there is need for further investigations on various physicochemical properties of nebulizer fluid as well as improvement in percentage FPF.
