Article Sidebar
Published:
Feb 15, 2022Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Signal processing techniques for the spectrophotometric quantitation of binary mixture of dapagliflozin and saxagliptin: A comparative study
Abstract
Purpose: To investigate the advantages and drawbacks of four signal processing methods for spectrophotometric quantitation of mixtures of dapagliflozin and saxagliptin.
Methods: The methods studied were numerical differentiation (ND), Savitzky-Golay filter (SG), discrete Fourier transform (DFT) and continuous wavelet transform (CWT). The resolution powers of the methods were compared via quantitative determination of dapagliflozin (DAP) and saxagliptin (SAX) in laboratory prepared mixtures. Furthermore, a new approach for validating robustness in spectrophotometric methods was developed, and the methods were compared using their robustness.
Results: Continuous wavelet transform (CWT) produced the best results regarding the analysis of the two drugs in different ratios. It also showed a lower limit of quantification (LOQ), when compared to each of the other methods. When the four methods were used for quantitation of pharmaceutical drug formulations, and subjected to validation in line with ICH regulations, they were found to be satisfactorily specific, accurate, precise and robust.
Conclusion: These results show that CWT technique is superior to the other three methods for analysis of drug mixtures with regard to sensitivity and resolving power. Thus, CWT can be used in the routine spectrophotometric analysis of pharmaceuticals in quality control laboratories.
