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Published:
Jan 20, 2022Keywords:
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Main Article Content
Effect of curcumin on the viability of SKOV3 cells and its probable mechanism of action
Abstract
Purpose: To study the influence of curcumin on the survival of SKOV3 cells and the potential molecular mechanism of action.
Methods: SKOV3 cell proliferation was measured using MTT assay. Gene expression levels were assayed using QRT-PCR assay, while protein expression was determined with western blotting.
Results: Cell viability was reduced by curcumin at doses of 20, 40 and 80 μM (p < 0.05) in a dose-based fashion. Protein expression levels of Bax, caspase-3 and caspase-9 were upregulated by curcumin, while Bcl-2 protein level was downregulated (p < 0.05).
Conclusion: These results demonstrate that curcumin inhibits cell proliferation by promoting the protein expressions of pro-apoptotic genes (Bax, caspase-3 and caspase-9) while suppressing Bcl-2 protein level. Therefore, curcumin might be a novel alternative therapy for ovarian cancer.
