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Published:
Jul 22, 2021Keywords:
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Main Article Content
Novel sulfamoylamino-containing cephalosporin derivatives, and their in vitro antibacterial properties
Abstract
Purpose: To prepare and develop new antibacterial agents with novel molecular structures.
Method: A series of novel sulfamoylamino-containing cephalosporin derivatives were synthesized. The in vitro antibacterial effects of the derivatives against Gram-positive bacteria (S. aureus, S. pneumonia and S. epidermidis), and Gram-negative bacteria (E. coli, P. aeruginosa, and K. pneumonia) were investigated.
Results: Compounds 13a and 13b exhibited excellent antibacterial effects against all the Gram-positive and Gram-negative bacteria tested, when compared with other cephalosporin derivatives.
Conclusion: Of these new cephalosporin derivatives, compounds 13a and 13b show the most potent antibacterial activity and would need to be further investigated.
