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Published:
Jul 9, 2021Keywords:
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Main Article Content
Effectiveness of different resuscitation methods for severe uncontrolled hemorrhagic shock in a dog model
Abstract
Purpose: To compare the effects of pituitrin resuscitation, hypertonic saline resuscitation and limited fluid resuscitation on a novel dog model of severe uncontrolled hemorrhagic shock (UCHS).
Methods: Severe UCHS was produced in healthy Chinese dogs (n = 24) using a standard method. The hemorrhaged dogs were randomly divided into three groups of 8 dogs each: vasopressin group (group A), hypertonic saline group (group B), and low-volume fluid resuscitation group (group C). Group A received pituitrin at an initial dose of 0.1U/kg intravenously, which was thereafter reduced to 0.04 U/kg/min. Group B dogs received 7.5 % hypertonic saline (6 mL/kg), while dogs in group C were treated with 6 % hydroxyethyl starch (HES) 200/0.5. Mean arterial pressure (MAP) of the dogs was maintained between 50 and 55 mmHg, and after 1 h, full-volume resuscitation was administered. Hemodynamic parameters, blood gas, levels of inflammatory factors and blood loss were assessed at different time points.
Results: Compared with group A, hemodynamic parameters in group B were higher; hematocrit of group B was lower; IL-10 of groups B and C were reduced, but TNF-α, TNF-α/IL-10 and ACTH were elevated (p < 0.05). Relative to group C, base deficits in groups A and B were low. During uncontrolled hemorrhage phase, blood loss in group B was higher than that in other groups (p < 0.05).
Conclusion: The results obtained in this study suggest that pituitrin resuscitation produces relatively optimal effect through effective maintenance of coronary perfusion pressure (CPP) and reduction of inflammatory responses.
