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Skin care benefits of bioactive compounds isolated from Zanthoxylum piperitum DC. (Rutaceae)


Sung Chun Kim
Mi Yeon Moon
Ha Youn Lee
Jungha Kim
Moon Sik Chang
Joonseok Cha

Abstract

Purpose: To investigate skin care efficacies of Zanthoxylum pipetitum extract and isolated compounds.


Methods: Ethanol extracts of leaves, branches and fruits of what were partitioned into n-hexane, chloroform, ethyl acetate, n-butanol and aqueous layers and some fractions were further analyzed to isolate five compounds. The isolated compounds were identified based on the proton and carbon nuclear magnetic resonance (NMR) spectra. Cosmetic efficacy tests of the extracts and isolated compounds were evaluated by in vitro tests.


Results: Phytochemical studies of the chloroform and ethyl acetate layers led to the isolation of five compounds; quercitrin (1), afzelin (2), hydroxy-α-sanshool (3), α-sanshool (4) and hyperoside (5). In activity tests, the extracts showed inhibitory activity against inflammation response and melanin synthesis, and induction of procollagen type I C-peptide (PIP). Among the isolated compounds, hydroxy-α-sanshool (3) and α-sanshool (4) displayed significant anti-inflammatory activity.


Conclusion: The results demonstrate that Z. piperitum extract and its active compounds possess a significant potential as a cosmeeutical agent for enhancing skin quality.


Journal Identifiers


eISSN: 1596-9827
print ISSN: 1596-5996