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Duloxetine alleviates high light-induced anxiety-related behaviors in Wistar rats


Hasan Çalışkan
Koray Hamza Cihan
Emel Güneş
Ahmet Ergün
Mitat Can Öztürk
Şükrü Hakan Gençer
Süleyman Kılınç
Zakir Osmanov
Mehmet Oğuzhan Kaya
Murat Kılıçdağı

Abstract

Purpose: To investigate the effect of subchronic duloxetine treatment on high light-induced anxietyrelated behaviors in Wistar rats.


Methods: Adult male Wistar rats (n = 30) were randomly assigned to three groups of rats (10 rats/group): control group, 30 mg/kg duloxetine group, and 60 mg/kg duloxetine group. Intraperitoneal injection of duloxetine was given once a day for ten days. The anxiolytic effect of duloxetine in the rats was assessed using light/dark box (LDB) anxiety test.


Results: Anxiety-related behaviors were significantly reduced in duloxetine-treated rats, when compared with control group. The reductions were not dose-dependent (light zone time and latency time were significantly increased, while dark zone time decreased significantly, p < 0.05). The number of rearings significantly increased in 30 mg/kg duloxetine group, relative to control and 60 mg/kg duloxetine groups (p < 0.05). However, there were no significant differences in the number of light-todark entrances among the groups (p > 0.05).


Conclusion: These results show that subchronic treatment with duloxetine alleviates anxiety-related behaviors in Wistar rats.


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eISSN: 1596-9827
print ISSN: 1596-5996