Article Sidebar
Published:
Jun 24, 2021Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Gastroprotective and ulcer healing properties of ethanol extract of Alpinia conchigera rhizome in experimentally induced gastric ulcer in rats
Abstract
Purpose: To investigate the gastroprotective effect of Alpinia conchigera rhizome in an ulcer rat model.
Method: Sprague-Dawley rats were treated with ethanol extract of Alpinia conchigera at doses of 75 and 150 mg/kg body weight. After 28 days, the rats were sacrificed. Ulcer index, total acidity, pH, hemoglobin levels, and hemorrhagic lesions were determined through macroscopic assessment and histopathological examination. The levels of lipid peroxidation (LPO), superoxide dismutase (SOD), and catalase (CAT), and inflammatory markers (TNF-α, IL-1β, and IL-6) were also determined.
Results: Alpinia conchigera significantly reduced ulcer index, total acidity, pH and hemoglobin levels (p < 0.05). Results from histology revealed that the extract protected the mucosa from lesions. Moreover, the extract significantly enhanced gastric mucosal activities of SOD and CAT, and decreased LPO levels and plasma concentrations of TNF-α, IL-1β, and IL-6 (p < 0.05).
Conclusion: These results validate the traditional claims on the gastroprotective effects of Alpinia conchigera as revealed through its antioxidant and ulcer-healing properties by stimulation of important cellular mechanisms.
