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Published:
Apr 9, 2020DOI:
10.4314/tjpr.v19i3.8Keywords:
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Main Article Content
Analgesic effect of flurbiprofen ester and its effect on serum inflammatory factors and Β-endorphin expression in rats with incision pain
Abstract
Purpose: To study the analgesic effect of flurbiprofen ester in rats with incision pain, and its effect on serum inflammatory factors and β-endorphin expression.
Methods: Seventy-five (75) healthy rats with foot contraction threshold induced by basic mechanical stimulation were randomly assigned to control, model control and treatment groups. Flurbiprofen was administered in 3 doses: 5, 10 and 15 mg/kg. Then, 3 mL of ventricular blood was taken from anesthetized rats and the serum levels of tumor necrosis factor-α (TNF- α), interleukin-1 β, interleukin-6 and β-endorphin were measured. The expression of β-endorphin in the spinal cord of rats with lumbar enlargement and ARC was determined.
Results: The TNF- α, interleukin-1 β and interleukin-6 concentrations were significantly lower in treatment group than in model rats, and decreased with time and dose (p < 0.05). In the treatment group, the level of serum β-endorphin decreased with increase in dose at 1 h, but increased with increase in dose at 5 h and 10 h (p < 0.05). The levels of β-endorphin in the spinal cord, was significantly lower in model rats than in control rats (p < 0.05).
Conclusion: Pre-administration of flurbiprofen ester reduces serum inflammatory factors and upregulates β-endorphin expression in rats with incision pain. Thus, it flurbiprofen exerts analgesic effect.
Keywords: Flurbiprofen ester, Incision pain, Rat, Analgesia, Inflammatory factor, β-endorphin
