Article Sidebar
Published:
Mar 12, 2019Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of three kinds of anaesthetic drugs on postoperative recovery, regulatory T cells and T lymphoid cells in elderly patients
Abstract
Purpose: To investigate the effect of three anaesthetic drugs on postoperative recovery, regulatory T cells and T cell subset levels in elderly patients.
Methods: The patients were randomly divided into groups A, B and C (42 patients per group). Group A received intravenous remifentanil, dexamethasone, dexmedetomidine and propofol, followed by continuous intraoperative inhalation of sevoflurane and continuous intravenous pumping of remifentanil. Group B was given intravenous propofol and midazolam, followed by continuous intraoperative inhalation of sevoflurane, while Group C received intravenous etomidate and rocuronium, with continuous intraoperative inhalation of sevoflurane. The preoperative or 24-h postoperative T regulatory cells (CD4+ CD25+) and T cell subsets (CD4+ and CD8+) were determined for each group.
Results: MMSE scores in the three groups were lower than their pre-operation scores (p < 0.05). There were significant reductions in 24-h postoperative serum CD4+ CD25+ and CD4+ levels, with higher reductions in group B (p < 0.05). In contrast, CD8+ increased in all groups, but was lower in group B than in the other two groups (p < 0.05).
Conclusion: These findings strongly suggest that propofol, midazolam and sevoflurane have rapid onset of action and recovery, which improves the comfort of patients while decreasing negative impact on the function of the immune system. Furthermore, these anaesthetic agents enhance the recovery of elderly patients.
Keywords: Anaesthesia, Cognitive function, Regulatory T cells, T cell subsets
