Article Sidebar
Published:
Mar 12, 2019Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of Bushen Jiangu decoction on ovariectomyinduced osteoporosis in rats
Abstract
Purpose: This study aimed to determine the therapeutic effect of Bushen Jiangu Decoction (BJD) on osteoporosis (OS) in rats.
Methods: The animals were divided into the following groups: control group, rats received no treatment; ovariectomy (OVX) group, rats subjected to OVX surgery and were treated with normal saline; OVX + Fosamax group, rats that received OVX and were treated with 2 mg/kg/week of Fosamax; low-dose BJD (40 mg/kg/day), medium-dose BJD (80 mg/kg/day) and high-dose BJD (160 mg/kg/day) groups, where rats received OVX surgery with BJD doses of 40, 80 and 160 mg/kg/day, respectively. At four weeks after treatment with OVX, Fosamax or BJD was orally administered for four months. Bone mineral density (BMD) was assessed, while serum hormone, serum levels of follicle-stimulating hormone (FSH), alkaline phosphatase (ALP), estradiol (E2), luteinizing hormone (LH), osteocalcin (OC) and telopeptides of collagen type I (CTx) were measured by enzyme linked immunosorbent assay (ELISA).
Results: The results demonstrated that the reduced BMDs of L4 femurs and vertebrae were inhibited by BJD. Furthermore, BJD significantly elevated the serum levels of FSH, E2 and LH in OS rats. Furthermore, the serum CTx, ALP and OC levels of these rats dramatically decreased, when compared to the OVX group.
Conclusion: These findings suggest that BJD can improve OVX-induced OS.
Keywords: Bushen Jiangu decoction, Osteoporosis, Bone mineral density, Serum biochemistry
