Article Sidebar
Published:
Oct 3, 2018Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Efficacy of combined atorvastatin calcium, Salviae miltiorrhizae and ligustrazine hydrochloride injection in cerebral infarction patients
Abstract
Purpose: To study the effect of a combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection on serum levels of ferritin (SF), C-reactive protein (CRP) and hypoxia-inducible factor 1α(HIF-1α) in cerebral infarction patients.
Methods: A total of 60 cerebral infarction patients (confirmed by CT or MRI scan) were randomly assigned to control group and observation group (30 patients/group). Both groups received routine treatments. All patients took atorvastatin calcium, but those in the observation group were treated with Salviae miltiorrhizae and ligustrazine hydrochloride injection, in addition to atorvastatin hydrochloride for 14 days, with 7 days as treatment course. The levels of SF, CRP and HIF-1α were determined before and after treatment, to assess clinical efficacy and safety.
Results: In both groups, SF, CRP and HIF-1α levels were lower after treatment than before treatment (p < 0.05). NIHSS score and platelet activation indices were also significantly reduced, relative to control (p < 0.05).
Conclusion: The combination of atorvastatin calcium with Salviae miltiorrhizae and ligustrazine hydrochloride injection can control vascular inflammatory reactions by decreasing the levels of SF, CRP and HIF-1α. Thus, it may be beneficial in the clinical management of cerebral infarction.
Keyword: Cerebral infarction, Atorvastatin calcium, Salviae miltiorrhizae, Ligustrazine hydrochloride injection
