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Published:
May 9, 2018Keywords:
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Main Article Content
Evaluation and toxicological quantification of undeclared allopathics and adulterated synthetic steroids in herbal antihypertensive preparations
Abstract
Purpose: To evaluate raw and finished dosage form of herbal antihypertensives for quantification of undeclared allopathic contents and synthetic steroids adulteration in each unit and in total daily dose.
Methods: Analysis of herbal products for allopathic drugs adulteration was carried out using HPLC techniques. The methods were reproduced with optimized extraction and chromatographic conditions. Calibration curves were reconstructed for validation purposes.
Results: The herbal products were adulterated with various synthetic drugs. The concentrations (mean ± SD) were: atenolol (50.06 ± 1.20 mg/unit dose), propranolol (20.30 ± 0.44 mg/unit dose, 28.26 ± 0.06 mg/unit dose, 15.40 ± 1.58 mg/unit dose), ACE inhibitors i.e. captopril (52.99 ± 0.49 mg/unit dose) and frusemide (42.02 ± 0.88 mg/unit dose). For the synthetic steroids, the levels (mean ± SD) were prednisolone (13.67 ± 0.50 mg/unit dose), methyl prednisolone (4.18 ± 0.02 mg/unit dose), betamethasone (0.56 ± 0.06 mg/unit dose) and dexamethasone (1.75 ± 0.11 mg/unit dose).
Conclusion: Administration of adulterated remedies can cause severe toxicity and is a serious safety concerns for public health. Therefore, to maximize consumer safety, appropriate rules and regulations should be developed for registration of herbal remedies.
Keywords: Herbal medicines, Adulterants, Allopathic drugs, Synthetic steroids
