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Published:
Mar 7, 2018Keywords:
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Main Article Content
Population pharmacokinetics of vancomycin in Jordanian patients
Abstract
Purpose: To characterize vancomycin pharmacokinetic properties in a Jordanian population and identify patients’ characteristics that influence vancomycin disposition.
Method: A non-linear mixed-effects modeling was applied to evaluate vancomycin population pharmacokinetic parameters in Jordanian patients using NONMEM software. Vancomycin concentrations were obtained retrospectively from patients’ medical records. Demographic, clinical, medication-related, and medical history data were collected and examined as potential predictors of vancomycin disposition.
Results: A total of 164 plasma vancomycin measurements from 110 patients, including neonates, older children and adults were collected. Vancomycin pharmacokinetics was described using a onecompartment model. Based on NONMEM objective function value, the selection of other models (e.g., two or three compartments) did not improve the performance of the pharmacokinetic model. Identified predictors of vancomycin clearance include: weight, serum creatinine, chronic renal failure, acute kidney injury and gender. Vancomycin volume of distribution was associated with weight and n-acetylcystine administration.
Conclusion: The present analysis is a preliminary step toward developing a vancomycin dosing algorithm in Jordanian population.
Keywords: Vancomycin, Population pharmacokinetics, NONMEM
