Article Sidebar
Published:
Mar 7, 2018Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Healing effect of Shaoshang Yuhe yihao on burns in rats
Abstract
Purpose: To investigate the healing effect of Shaoshang Yuhe yihao (SYY) in a deep second-degree burns model in rats.
Methods: Female Wistar rats, weighing 200 - 220 g, were subjected to deep second-degree skin burns by electrical scald instrument. The animals were divided into three groups as follows: (1) second-degree burns model (control) group, (2) moist exposed burns ointment-treated group (positive control drug), and (3) SYY groups. The rats were treated with SYY for 21 consecutive days. The rate of healing, scabs dropped time and re-epithelialization time were observed every three days for 21 days after burns injury. Samples were collected from treated rats after sacrificing the animals on the 1st, 2nd, 5th, 9th, 14th, and 21st day post-burn creation, respectively. Plasma interleukin-1 (IL-1) levels were evaluated, and the tissue expressions of transforming growth factor-beta (TGF-β) were determined along with skin histopathology. The burned tissues were examined histologically to confirm the degree of burns and healing condition.
Results: The results showed that the scabs drop time decreased (p < 0.05), and healing accelerated after treatment with SYY in the burns injury rats (94.6 ± 2.6 %, p < 0.05). Furthermore, the expressions of TGF-β significantly increased in the tissue (329.4 ± 8.2 pg/mL, p < 0.05) at day 14; However, the levels of inflammatory factors in plasma decreased (11.3 ± 1.7 pg/mL, p < 0.05). On the 21st day after burns injury, the injured tissue treated with SYY was almost (> 90 %) covered with healthy epithelial tissue and new epidermis, and showed complete epithelialization of the burns injury area.
Conclusion: The results confirm the curative effects of SYY on burns injuries in rats. Thus, the herbal preparation has potentials to be developed for clinical application in burns cases.
Keywords: Shaoshang Yuhe yihao, Second-degree burns, Healing, Scabs drop time, Moist exposed burns ointment
