Article Sidebar
Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Ixeris dentata (Thunb) Nakai attenuates cognitive impairment in MPTP-treated mouse model of Parkinson's disease
Abstract
Purpose: To evaluate the cognition-enhancing effect of Ixeris dentata (Thunb) Nakai in a mouse model of Parkinson's disease (PD).
Methods: MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced mouse model of PD was used to evaluate the effect of Ixeris dentata (IDE) extract on the alteration of behavioral responses using rotarod and passive avoidance tests. The effect of IDE on oxidative stress levels were analyzed based on superoxide dismutase (SOD) and catalase (CAT) enzyme levels, and lipid peroxidation (LPO) in brain tissues.
Results: MPTP (20 mg/kg, ip)-induced mice resulted in a significant (p < 0.01) behavioral deficiencies in locomotor behavior (from 53.15 ± 1.01 to 23.56 ± 1.04) and cognitive functions (from 297 ± 2.47 to 201.17 ± 3.23 s) compared with their respective control groups. Administration of IDE (20, 40 and 80 mg/kg, po) for three weeks significantly and dose-dependently improved (p < 0.001 at 80 mg/kg) locomotor and cognitive deficits in MPTP- treated mice. IDE treatment also significantly (p < 0.01 at 80 mg/kg) inhibited decrease in superoxide dismutase and catalase enzyme activities, and lipid peroxides in MPTP-treated mice in brain tissues.
Conclusion: IDE exhibits good protection against MPTP-induced behavioral deficits via potential antioxidant defense mechanisms. Therefore, IDE could potentially be developed as a therapeutic approach for the treatment of neurodegenerative diseases.
Keywords: Ixeris dentata, Neurodegenerative disease, MPTP, Parkinson's disease, Oxidative stress
