Article Sidebar
Published:
Sep 6, 2017DOI:
10.4314/tjpr.v16i8.9Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Preparation and physicochemical evaluation of transdermal aerosols containing ketoprofen
Abstract
Purpose: To prepare transdermal ketoprofen metered-dose aerosol formulations containing menthol and isopropyl myristate (IPM) as penetration enhancers and to evaluate their physicochemical and permeation properties.
Methods: Selected ratios of ketoprofen, ethanol, polyvinylpyrrolidone K30 (PVP K30, anti-nucleant), and penetration enhancers were mixed and filled into aluminum aerosol cans with hydrofluoroalkane- 134a as propellant. The physicochemical properties of the films, and their ex vivo permeation properties in rat skin were investigated over a 24-h period. Rat skin was exposed to a definite dose of each ketoprofen film to determine the quantity of drug in the receptor compartment over a 24-h period.
Results: All the transdermal formulations showed good integrity and film uniformity. Formulations with permeation enhancers presented higher rates of skin penetration compared to control formulations. Formulations containing 3% PVP and 5% IPM produced the highest permeation rates (Jss, 85.35 μg/cm2/h).
Conclusion: These results indicate that incorporation of antinucleant polymer and permeation enhancers in aerosols containing ketoprofen enhances aerosol stability and drug permeation through rat skin.
Keywords: Ketoprofen, Antinucleant, Permeation enhancer, Topical aerosol, Transdermal delivery
