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Dec 7, 2016Keywords:
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Main Article Content
Effect of ginseng root polysaccharides on cutaneous wound repair in mice
Abstract
Purpose: To evaluate the healing activity of water ginseng (Panax ginseng C.A. Meyer) polysaccharide (WGP) in vivo.
Methods: Mice were divided into four groups: group 1 was the control, and groups 2–4 were treated with WGP (15 mg or 30 mg) or mouse epidermal growth factor (mEGF, 0.1 mL, 2000 IU/mL), respectively. Full-thickness excision wounds were made on the back of each mouse. Wound areas were imaged, and wound contraction (%) was calculated. Histological observation and analysis of collagen content were performed using standard biochemical methods.
Results: Wound contraction and the period of epithelialization in WGP groups were significantly different from those of control. The 30 mg WGP group showed 85.0 % wound healing, while control group showed only 65.8 % wound healing (p < 0.001) 10 days after the operation. WGP also promoted the formation of collagen in a dose-dependent manner. Histological examination confirmed that fibroblasts and new blood vessels were more abundant in WGP group than in control group.
Conclusion: Topical application of WGP stimulates wound contraction and accelerates healing. This may be due to the ability of WGP to enhance the functions of macrophages and myeloid hematopoietic cells, resulting in increased fibroblast division, collagen synthesis, and production of blood cells during wound healing.
Keywords: Panax ginseng, Wound healing, Ginseng, Polysaccharides, Fibroblast, Hydroxyproline, Collagen
