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Published:
Feb 27, 2009Keywords:
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The effect of Garcinia kola extract on lipopolysaccha-ride-induced tissue damage in rats
Abstract
Purpose: To study the effect of the crude methanol extract of Garcinia kola seed on lipopolysaccharide (LPS)-induced tissue damage in rats Methods: A total of 16 rats were split equally into four treatment groups: Normal controls, LPS-treated only, LPS-treated + 100 mg/kg body weight (b.w.) extract, LPS-treated + 250 mg/kg b.w. extract. LPS
was administered via the intraperitoneal route once and the extract orally administered to the rats for 14 days. Indices of liver and kidney function were later assessed.
Results: The results showed that LPS caused marked elevations in the blood levels of alanine aminotransaminase, aspartate aminotransaminase, creatinine, urea, nitric oxide and a significant reduction in the catalase activity in both liver and kidney. The thiobarbituric acid reactive species were also increased in liver. These levels were brought to near control values when the rats were fed with the extract. The changes were more pronounced in the rats given the 250 mg/kg b.w. of the extract. Conclusion: The data suggest that Garcinia kola significantly reduced the tissue damage induced by LPS which may be dose-dependent. This is probably due to the interaction of the various phytochemicals with LPS and/or to the fact that the extract possesses significant antioxidant properties.
Keywords: Garcinia kola, lipopolysaccharide, creatine, urea, hepatotoxicity, nephrotoxicity
Tropical Journal of Pharmaceutical Research Vol. 8 (1) 2009: pp. 27-31
