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Apr 3, 2008Keywords:
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Anti-ulcer and Anti-inflammatory Effects of Hydroalcohol Extract of Aloe buettneri A. Berger (Lilliaceae)
Abstract
Purpose: Aloe buettneri A. Berger is commonly used in Togolese folk medicine to treat inflammation
and gastric ulcer. In this study we investigated the anti-oedema, analgesic, antipyretic and ulcer healing
properties of the hydro-alcohol extract of their leaves.
Methods: Rat oedema paw were induced by the injection of 0.1 ml of formaldehyde 1%, tail flick
method is used to study analgesic property, hyperthermia was induced by subcutaneous injection of
15% of a brewers\' yeast suspension at dose of 10 ml/kg and ulcers were induced by ethanol or
HCl/ethanol mixture.
Results: The extract showed anti-inflammatory properties at doses between 250-500 mg/kg. It
inhibited, in a dose- dependent manner, the oedema induced by 0.1 ml of formaldehyde 1%. Scores of
73.70% and 83.63% were obtned when the doses of extract administered were 100 and 500 mg/kg,
respectively. The tail flick analgesic index showed an increase of 36.56% when the dose was 500
mg/kg. The extract decreased significantly the hyperthermia induced by the injection of yeast. 1000
mg/kg of the extract inhibited 63.77% of the gastric lesion induced by acid-water-ethanol mixture while
daily administration of the same dose accelerated the cicatrisation of gastric ulcer induced by 95%
ethanol.
Conclusion: The results obtained show that the hydro-alcohol extract of Aloe buettneri A. Berger
(Lilliaceae) has anti-inflammatory, anti-ulcer and wound healing properties
Keywords: Aloe buettneri, oedema, analgesic, hyperthermia, ulcer.
Tropical Journal of Pharmaceutical Research Vol. 7 (1) 2008: pp. 907-912
