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Adsorptive property of kaolin in some drug formulations
Abstract
Method: Chloroquine and chlorpheniramine tablets were formulated with powder mixtures containing various concentrations of kaolin. The effect of kaolin on the physical properties of the tablets were examined and compared with those of standard lubricants like magnesium stearate and talc. Chloroquine and chlorpheniramine tablets and powders of amoxicillin/clavulanic acid oral powder and ampicillin/cloxacillin injection were also mixed with and without various concentrations of kaolin in water. Chemical assay of the drugs in the solutions were determined over time.
Results: Kaolin significantly reduced the amount of each of the drugs in the solutions containing kaolin.
Conclusion: Kaolin reduces the amount of some drugs when incorporated in drug formulations. Therefore, its inclusion in such drug formulations should not be encouraged.
Keywords: Adsorption, ampicillin/cloxacillin, amoxicillin/clavulanic acid, chloroquine, chlorpheniramine, drug formulation, kaolin.
Tropical Journal of Pharmaceutical Research 2003; 2(1): 155-159
