Article Sidebar
Published:
Dec 8, 2015Keywords:
Article Details
Submission of a manuscript to this journal is a representation that the manuscript has not been published previously and is not under consideration for publication elsewhere.
All authors named in each manuscript would be required to sign a form (to be supplied by the Editor) so that they may retain their copyright in the article but to assign to us (the Publishers) and its licensees in perpetuity, in all forms, formats and media (whether known or created in the future) to (i) publish, reproduce, distribute, display and store the contribution, (ii) translate the contribution into other languages, create adaptations, reprints, include within collections and create summaries, extracts and/or abstracts of the contribution, (iii) create any other derivative works(s) based on the contribution, (iv) to exploit all subsidiary rights in the contribution, (v) the inclusion of electronic links from the contribution to third party material where-ever it may be located, and (vi) license any thrid party to do any or all of the above.
Main Article Content
Effect of Alcohol Extract of Zataria multiflora (Boiss), Satureja bachtiarica (Bunge) and Zaravschanica membranacea (Boiss) on Immuno-Hematologic Factors in Rats
Abstract
Purpose: To determine the effect alcohol extract of Zataria multiflora, Satureja bachtiarica and Zaravschanica membranacea on immunohematologic factors in Wistar rats.
Methods: Wistar rats were randomly allocated to seven treatment groups which consisted of control group with water and feed only (1); 200 mg. kg-1 Z. membranacea (2); 400 mg. kg-1 Z. membranacea (3); 200 mg. kg-1 S. bachtiarica (4); 400 mg. kg-1 S. bachtiarica (5); 200 mg. kg-1 Z. multiflora (6) and 400 mg. kg-1 Z. multiflora (7). Erythrocyte counts (RBC), packed cell volumes (PCV), haemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), Translocation and Assembly Module (Tam) protein, IgM and albumin were measured after 29 days.
Results: Z. membranacea at 200 mg kg-1 showed the highest level of Tam-protein content (p < 0.05). Z. multiflora boiss at 400 mg kg-1 produced higher levels of immunoglobulin M (IgM) compared to S. bachtiarica and Z. multiflora (p < 0.05). Both Z. membranacea and S. bachtiarica at 200 mg. kg-1 caused a significant increase in albumin levels in the rats (p < 0.05). Z. multiflora at 400 mg. kg-1 had the highest effect on white blood cells (WBC) while S. bachtiarica produced the highest effect on neutrophils (Nut) (p < 0.05). Z. membranacea and Z. multiflora at 200 mg. kg-1 showed significantly higher levels of monocytes (Mon) % (p < 0.05). Z. multiflora and S. bachtiarica at 400 mg. kg-1 showed a significant effect on phagocytosis % (p < 0.05) whilst S. bachtiarica at 400 mg.kg-1 had a significant effect on phagocytosis number (p < 0.05).
Conclusion: The alcohol extracts of Z. multiflora Z. membranacea and S. bachtiarica extracts are capable of stimulating the immune defense mechanism without causing undesirable effects on hematological parameters.
Keywords: Zataria multiflora, Satureja bachtiarica, Zaravschanica membranacea, Immunoglobulin, Serum albumen, Immunohematologic factors
